- PII
- S19982860S0132342325040149-1
- DOI
- 10.7868/S1998286025040149
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 51 / Issue number 4
- Pages
- 706-714
- Abstract
- Derivatives of 1,2,4-triazole are very important in the pharmaceutical industry. In this work, we synthesized new 5-phenyl-1,2,4-triazole-3-thione 2-deoxyribosides with bulky substituents using an enzymatic transglycosylation reaction. Their antiviral activity against herpes simplex virus type 1 was investigated. The results showed that both cytotoxicity and antiviral activity increase with increasing length of the substituent.
- Keywords
- 1,2,4-триазолы аналоги нуклеозидов нуклеозидфосфорилазы противовирусная активность
- Date of publication
- 29.05.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 15
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