RAS BiologyБиоорганическая химия Russian Journal of Bioorganic Chemistry

  • ISSN (Print) 0132-3423
  • ISSN (Online) 1998-2860

Enzymatic Synthesis and Molecular Docking Studies of Substituted 5-Phenyl-1,2,4-triazole-3-thione Deoxyribosides

PII
S19982860S0132342325040149-1
DOI
10.7868/S1998286025040149
Publication type
Article
Status
Published
Authors
Volume/ Edition
Volume 51 / Issue number 4
Pages
706-714
Abstract
Derivatives of 1,2,4-triazole are very important in the pharmaceutical industry. In this work, we synthesized new 5-phenyl-1,2,4-triazole-3-thione 2-deoxyribosides with bulky substituents using an enzymatic transglycosylation reaction. Their antiviral activity against herpes simplex virus type 1 was investigated. The results showed that both cytotoxicity and antiviral activity increase with increasing length of the substituent.
Keywords
1,2,4-триазолы аналоги нуклеозидов нуклеозидфосфорилазы противовирусная активность
Date of publication
29.05.2025
Year of publication
2025
Number of purchasers
0
Views
15

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