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RAS BiologyБиоорганическая химия Russian Journal of Bioorganic Chemistry

  • ISSN (Print) 0132-3423
  • ISSN (Online) 1998-2860

2-Fluorocordycepin: Chemoenzymatic Synthesis and Study of Anticancer Activities In Vitro

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PII
S19982860S0132342325030105-1
DOI
10.7868/S1998286025030105
Publication type
Article
Status
Published
Authors
A. O. Arnautova
  • Affiliation:
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
    Engelhardt Institute of Molecular Biology RAS
K. V. Antonov
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
E. A. Zorina
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
M. A. Simonova
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
A. S. Paramonov
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
O. C. Zhukova
  • Affiliation: N.N. Blokhin National Medical Research Center of Oncology
M. V. Kiselevskiy
  • Affiliation: N.N. Blokhin National Medical Research Center of Oncology
A. L. Kayushin
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
I. V. Fateev
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
E. V. Dorofeeva
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
B. Z. Eletskaya
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
M. Ya. Berzina
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
O. S. Smirnova
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
T. V. Egorova
  • Affiliation: Moscow Pedagogical State University
R. S. Esipov
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
A. I. Miroshnikov
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
I. D. Konstantinova
  • Affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Volume/ Edition
Volume 51 / Issue number 3
Pages
469-485
Abstract
Two methods for obtaining 2-fluorocordycepin were proposed and implemented: chemical synthesis from 2-fluoroadenosine with a yield of 34% and chemical-enzymatic synthesis with a yield of 66%, including the production of 3-deoxyerythropentofuranose-1-phosphate and subsequent transglycosylation using E. coli purine nucleoside phosphorylase. The cytotoxic activity of 2-fluorocordycepin in vitro was assessed. It was shown that 2-fluorocordycepin exhibits an anti-metabolic effect on a number of tumor cell lines (Jurkat, Raji, MCF-7, THP-1, U937, A549, LS174T), which allows us to consider this compound as a promising candidate for the development of antitumor drugs.
Keywords
аналоги нуклеозидов 2-фторкордицепин пуриннуклеозидфосфорилаза
Date of publication
07.12.2025
Year of publication
2025
Number of purchasers
0
Views
7

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