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RAS BiologyБиоорганическая химия Russian Journal of Bioorganic Chemistry

  • ISSN (Print) 0132-3423
  • ISSN (Online) 1998-2860

Platinum Polyoxoniobate: Stability, Cytotoxicity, and Cellular Uptake

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PII
S0132342325020141-1
DOI
10.31857/S0132342325020141
Publication type
Review
Status
Published
Authors
A. V. Yudkina
  • Affiliation: Novosibirsk State University
Volume/ Edition
Volume 51 / Issue number 2
Pages
362-371
Abstract
Platinum polyoxometalates are Pt (IV) complexes containing bulky cluster ligands. We have shown previously that platinum polyoxoniobate [(Nb6O19)2{Pt(OH)2}2]12− (Pt-PON1) containing two Pt centers can covalently bind DNA. Here we have addressed the structural stability of Pt-PON1 and its conjugate with guanine at the N7 position, cytotoxicity of this compound, and its accumulation in living cells. Quantum mechanical modeling showed that the Pt-PON1 complex is unstable outside the crystal lattice, while its conjugate with guanine likely undergoes structural rearrangement quite easily. A decrease in the survival of Escherichia coli XL1-Blue and DH5α strains and human HEK293T and MCF-7 cell lines was observed already at 20 μM Pt-PON1 but at higher concentrations the compound was poorly soluble in biologically compatible media. Atomic emission spectroscopy for Pt and Nb showed that Pt-PON1 is efficiently taken up by human cells in a stoichiometry corresponding to the original complex. Thus, platinum polyoxometalates, provided their solubility can be improved, may be considered as promising antitumor agents.
Keywords
полиоксометаллаты препараты платины повреждение ДНК цитотоксичность
Date of publication
09.11.2025
Year of publication
2025
Number of purchasers
0
Views
42

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