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RAS BiologyБиоорганическая химия Russian Journal of Bioorganic Chemistry

  • ISSN (Print) 0132-3423
  • ISSN (Online) 1998-2860

Modern Laboratory Test-Systems as Platforms for Validation of Clinically Promising T-Cell Receptors

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PII
S19982860S0132342325050017-1
DOI
10.7868/S1998286025050017
Publication type
Review
Status
Published
Authors
R.V. Mungalov
  • Occupation: Faculty of Biology and Biotechnology
  • Affiliation:
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
    Institute of Translational Medicine, Pirogov Russian National Research Medical University
    National Research University "Higher School of Economics"
N.S. Vand
  • Affiliation: Institute of Translational Medicine, Pirogov Russian National Research Medical University
D.M. Chudakov
  • Affiliation:
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
    Institute of Translational Medicine, Pirogov Russian National Research Medical University
    Center for Molecular and Cellular Biology
E.A. Bryushkova
  • Occupation: Department of Molecular Biology
  • Affiliation:
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
    Institute of Translational Medicine, Pirogov Russian National Research Medical University
    Lomonosov Moscow State University
Volume/ Edition
Volume 51 / Issue number 5
Pages
731-742
Abstract
The development of therapeutic antigen-specific T-cell receptors (TCRs) requires comprehensive preclinical validation of their functional activity. One of the approaches in the development of new drugs for cell therapy based on antigen-specific T lymphocytes is the modification of autologous T lymphocytes with endogenous T-cell receptors. The present work reviews modern laboratory platforms used to assess key TCR characteristics: immunological synapse formation, specificity and affinity of antigen binding, activation of signalling pathways, cytokine production and cytotoxic potential. Particular attention is paid to the creation of model T-cell lines expressing transgenic TCRs, optimisation of HLA context of target cells and application of multiparametric technologies for immune response analysis. The prospects of using 3D organoid models for validation of functional activity of transgenic TCRs under conditions close to physiological ones, as well as for predicting their clinical efficacy are discussed. The presented approaches form the basis for rational selection of candidate receptors for their subsequent application in immunotherapy of tumours and chronic infections.
Keywords
Т-клеточные рецепторы репортерные системы иммунотерапия клеточная терапия
Date of publication
01.05.2025
Year of publication
2025
Number of purchasers
0
Views
7

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