- PII
- S19982860S0132342325030139-1
- DOI
- 10.7868/S1998286025030139
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 51 / Issue number 3
- Pages
- 516-522
- Abstract
- Condensation of 1-(4-alkoxyphenyl)ethanones with aromatic aldehydes in the presence of sodium hydroxide in an aqueous-ethanol solution yielded (2E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones. Subsequent oxidation of the latter with hydrogen peroxide in a water-ethanol system in a basic medium at room temperature yielded the corresponding epoxy derivatives. The effect of the synthesized compounds on tumor DNA methylation processes in vitro and the antitumor activity of [4-(pentyloxy)phenyl)](3-phenyloxiran-2-yl)methanone in vivo were assessed.
- Keywords
- (Е)-3-арил-1-(4-алкоксифенил)проп-2-ен-1-оны ароматические альдегиды конденсация оксироны опухолевая ДНК
- Date of publication
- 07.12.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 7
References
- 1. Гуревич П.А., Бардасов И.Н., Михайлов Д.Л., Лыщиков А.Н., Саттарова Л.Ф., Могильный Н.Г., Струнин Б.П. // Вестник Казанского технолог. университета. 2012. № 6.
- 2. Peretto I., Radaelli S., Parini C., Zandi M., Raveglia L.F., Dondio G., Fontanella L., Misiano P., Bigogno Ch., Rizzi A., Riccardi B. // J. Med. Chem. 2005. V. 48. P. 5705
- 3. Nagumo Y., Kakeya H., Yamaguchi J., Uno T., Shoji M., Hayashi Y., Osada Hir. // Bioorg. Med. Chem. Lett. 2004. V. 14. P. 4425
- 4. Eshtukova-Shcheglova E., Perevochshikova K., Eshtukov-Shcheglov A.V., Cheshkov D.A., Maslov M.A. // Fine Chemical Technologies. 2022. V. 17. P. 323. https://doi.org/10.32362/2410-6593-2022-17-4-323-334
- 5. Gomes A.R., Valera C.L., Tavares-da-Silva E.J., Roleira F.M.F. // Eur. J. Med. Chem. 2020. V. 201. P. 112327. https://doi.org/10.1016/j.ejmech.2020.112327
- 6. Ichimaru Y., Fujii T., Saito H., Sano M., Uchiyama T., Miyairi S. // Bioorg. Med. Chem. 2017. V. 25. P. 4665. https://doi.org/10.1016/j.bmc.2017.07.009
- 7. Джемилев У.М., Дьяконов В.А., Кадикова Г.Н., Джемилева Л.У., Газизуллина Г.Ф. // Патент РФ 2735664 C2 (2020).
- 8. Gomes A.R., Tavares-da-Silva E.J., Costa S.C., Varela C.L., Abrantes A.M., Gonçalves A.C., Alves R., Botelho M.F., Roleira F.M.F., Pires A.S. // Biochem. Pharm. 2024. V. 225. P. 116266. https://doi.org/10.1016/j.bcp.2024.116266
- 9. Montero V., Montana M., Khoumeri O., Correard F., Estève M.A., Vanelle P. // Pharmaceuticals (Basel). 2022. V. 15. P. 781. https://doi.org/10.3390/ph15070781
- 10. Baylin S.B., Herman J.G. // Trends Genetics. 2000. V. 16. P. 168.
- 11. Howell P.M., Jr., Liu Z., Khong H.T. // Pharmaceuticals. 2010. V. 3. P. 2022. https://doi.org/10.3390/ph3072022
- 12. Hakobyan N.Z., Isakhanyan A.U., Grigoryan G.S., Mkhitaryan R.P., Sargsyan H.R., Grigoryan A.S., Pahutyan N.H., Pogosyan A.E., Аrajyan G.M., Gasparyan H.V., Muradyan R.Y., Panosyan N.A., Israelyan S.G., Harutyunyan A.A. // Russ. J. Gen. Chem. 2024. V. 94. P. 2847. https://doi.org/10.1134/S1070363224110057
- 13. Vanyushin B.F., Masin A.L., Vasiliev V.K., Belozersky A.N. // Biochim. Biophys. Acta. 1973. V. 299. P. 397. https://doi.org/10.1016/0005-2787 (73)90264-5
