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RAS BiologyБиоорганическая химия Russian Journal of Bioorganic Chemistry

  • ISSN (Print) 0132-3423
  • ISSN (Online) 1998-2860

The Role of Phospholipid Derivatives of Cyclodextrins in the Formation of Stable Lipid Nanoparticles for Drug Delivery

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PII
S19982860S0132342325030013-1
DOI
10.7868/S1998286025030013
Publication type
Review
Status
Published
Authors
E. D. Belitskaya
  • Affiliation:
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
    Moscow Institute of Physics and Technology (National Research University)
V. A. Oleinokov
  • Affiliation:
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
    National Research Nuclear University “MEPhI”
A. V. Zalygin
  • Affiliation:
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
    Lebedev Physical Institute of the Russian Academy of Sciences, Troitsk Branch
Volume/ Edition
Volume 51 / Issue number 3
Pages
375-387
Abstract
This review article deals with physical methods for investigating the structural characteristics of inclusion complexes of supramers of phospholipid derivatives of cyclodextrins. Phospholipid derivatives of cyclodextrins are formed by attaching a phospholipid moiety to the cyclodextrin molecule. This modification imparts additional structural features to the cyclodextrin, increasing its solubility and stability in aqueous media. These new compounds can self-assemble in aqueous media into different types of supramolecular nanocomplexes. Biomedical applications are envisaged for nanoencapsulation of drug molecules in hydrophobic interchain volumes and nanocavities of amphiphilic cyclodextrins (serving as drug carriers or pharmaceutical excipients), antitumour phototherapy, gene delivery, and protection of unstable active ingredients by complexation of inclusions in nanostructured media. The focus is on the study of nanoparticle morphology, as efficient delivery systems must fulfil certain requirements. Classical physical methods cannot provide detailed information on the properties of potential structures for biomedical applications. For this purpose, the search for new non-invasive approaches is necessary.
Keywords
циклодекстрин функциональные спейсерные липиды адресная доставка лекарств молекулярная динамика малоугловое рентгеновское рассеяние
Date of publication
07.12.2025
Year of publication
2025
Number of purchasers
0
Views
8

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