- PII
- S0132342325020095-1
- DOI
- 10.31857/S0132342325020095
- Publication type
- Review
- Status
- Published
- Authors
- Volume/ Edition
- Volume 51 / Issue number 2
- Pages
- 308-317
- Abstract
- Enzymatic transglycosylation reactions catalysed by Lactobacillus leichmannii nucleoside deoxyribosyltransferase type II in the presence of 7-methyl-2′-deoxyguanosine and modified pyrimidine heterocyclic bases were studied. The choice of 7-methyl-2′-deoxyguanosine as a nucleoside donor of a carbohydrate residue allowed the enzymatic synthesis of 5-substituted 2′-deoxyuridine derivatives in high yields. Biologically active 2ʹ-deoxyuridine derivatives were obtained, three ones currently used in clinical practice in antiviral and antitumour therapy. The selected enzyme-catalyst, initial ratios of molar concentrations of substrates and the selected nucleoside-donor – source of carbohydrate residue will make it possible to develop environmentally friendly biochemical methods for the preparation of practically important modified nucleosides.
- Keywords
- Date of publication
- 09.11.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 44
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