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RAS BiologyБиоорганическая химия Russian Journal of Bioorganic Chemistry

  • ISSN (Print) 0132-3423
  • ISSN (Online) 1998-2860

Chemotherapeutic boron-containing homocysteinamides of human serum albumin

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PII
S0132342325010113-1
DOI
10.31857/S0132342325010113
Publication type
Article
Status
Published
Authors
M. Wang
  • Affiliation:
    Novosibirsk State University
    Institute of Chemical Biology and Fundamental Medicine SB RAS
Volume/ Edition
Volume 51 / Issue number 1
Pages
119-136
Abstract
Combination of boron neutron capture therapy and chemotherapy can provide good efficacy in a cancer treatment. Development of therapeutic constructs that combine these two functions, the possibility of in vitro and in vivo visualization and a convenient platform for selective delivery to the tumor is of great relevance today. In this study, we focused on human serum albumin, a well-known drug delivery platform. We developed constructs based on albumin functionalized with boron clusters, analogues of the chemotherapeutic molecule gemcitabine and signaling molecules. To create the constructs, we developed new analogues of homocysteine thiolactone containing closo-dodecaborate or cobalt bis(dicarbollide) and a gemcitabine analogue containing closo-dodecaborate attached to the C5 carbon atom of the nitrogenous base. We have demonstrated that addition of the gemcitabine analogue to the conjugate structure increases its cytotoxicity towards human glioblastoma cell lines. Among the final conjugates, the highest cytotoxicity is demonstrated by the structure containing cobalt bis(dicarbollide). The final structures accumulate well in the cytoplasm of cancer cells. The albumin conjugate containing cobalt bis(dicarbollide) and a boron-containing gemcitabine analogue is capable of accumulating in the nuclei of T98G cell lines. Thus, both final albumin-based constructs showed sufficient efficacy against the human glioma cell line in vitro. We expect that the therapeutic conjugates we have constructed will significantly increase cytotoxicity against cancer cells when irradiated with epithermal neutrons. Combining a chemotherapeutic residue and a boron-containing group in a single construct provides the potential for more effective glioma therapy.
Keywords
тераностики на основе борированного альбумина борсодержащие аналоги гемцитабина борсодержащие аналоги тиолактона гомоцистеина бор-нейтроно-захватная терапия средства доставки бора
Date of publication
09.11.2025
Year of publication
2025
Number of purchasers
0
Views
39

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