- PII
- S19982860S0132342325050077-1
- DOI
- 10.7868/S1998286025050077
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 51 / Issue number 5
- Pages
- 820-830
- Abstract
- Double-negative (DN) CD3CD4CD8 T lymphocytes represent a subgroup of unconventional peripheral T cells. Although their presence in peripheral blood is relatively low (3–5%), they play an important role in the development of inflammatory responses, oncological, autoimmune diseases, and allergic asthma. In the present study, we characterized the cytokine profile of CD3CD4CD8 DN T cells using multiplex technology with a wide panel of analytes. Our results demonstrate that the cytokine profile of proinflammatory αβTCRCD161 DN T cells includes the cytokines TNFα, IFNγ, IL-3, IL-13, and IL-27; the chemokines IL-8/CXCL8, MIG/CXCL9, MIP-1α/CCL3, MIP-1β/CCL4, and RANTES/CCL5; as well as the growth factors M-CSF and GM-CSF.
- Keywords
- дважды негативные T-клетки CD161 хемокины цитокиновый профиль цитокины проточная цитометрия мультиплексный анализ
- Date of publication
- 01.05.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 6
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